- 1745
- Col James Patton receives original 100,000-acre Woods River grant.
- 1755
- Drapers Meadow attacked by Indians; Mary Draper Ingles is taken hostage and escapes
- 1772
- Smithfield Plantation built by William Preston.
- 1776
- Montgomery County formed
- 1798
- Blacksburg founded by William Black
- 1801
- Solitude built (oldest building on
the Virginia Tech campus)
- 1840
- Price House at Lee and Wharton built
Blacksburg Female Academy incorporated. In 1858 it was sold to the Hunter's Lodge of F. and A.
Masons, and the name was changed to the Caldwell Masonic Female Institute.
- 1847
- First Presbyterian Church built (now South Main Cafe)
- 1849
- Blacksburg Savings Institution established (first bank in Montgomery County)
- 1850
- Rev. Charles Martin established a school
- 1851
- Methodists open Olin and Preston Institute with William R. White as principal
- 1852
- 1932
- New water system (owned by town) put into operation in September
- 1935
- Downtown Post Office built
Town installs lights on Main Street and street signs
- 1937
- Officer Dave Sumner, nicknamed "Highpockets," is first Blacksburg police officer
- 1941
- Bookmobile serivces provided to Montgomery, Radford, and Pulaski counties
- 1942
- Town buys first fire truck

- 1943
- Flood of Virginia Tech's lower quadrangle
- 1946
- Town buys first police car
- 1947
- First town buses begin runs
- 1948
- Virginia Polytechnic Institute hires Dr. Hung-yu Loh, physics professor from China
- 1949
- Police call light installed at the intersection of College Avenue and Main Street
- 1951
- Blacksburg First aid and Life Saving Crew founded
- 1952
- Virginia Tech Mall built
New Blacksburg High School built on Main and Eheart Streets
- 1953
- New athletic field completed at Blacksburg High School site
Litton Industries' Poly-Scientific plant opens
- 1954
- Blacksburg High School moves to new South Main Street building, now site of Blacksburg Middle School
Montgomery County Human Relations forms after Blacksburg minister Archie L. Richmond arrested at
segregated Wythe County park
Jack Goodwin is appointed the first chief of police by the Blacksburg Town Council
- 1955
- Blacksburg-Virginia Tech Water Authority amended to include Christiansburg
- 1957
- Town buys a radar set for speed control
- 1958
- Last run of the Huckleberry rail passenger service
- 1959
- Blacksburg Recreational Council formed
- 1961
- Blacksburg High School integrated by
Phillip Harmon Price, oral
history interview transcript available, and Anna Christine Price
- 1963
- Margaret J. Beeks Elementary School completed
Gilbert F. Linkous School completed
- 1964
- Renovated Smithfield Plantation house opens
Corning Glass Works opens south of Blacksburg
Blacksburg plant closes in 1984 and reopens in 1988
- 1965
- First Montgomery County Interstate 81 stretch opens
- 1966
- Last Huckleberry freight train leaves Blacksburg
Gables Shopping Center opens
- 1969
- Blacksburg Municipal Building on South Main Street constructed
U. S. 460 bypass opens
- 1970
- Blacksburg Branch of the Montgomery County Library opened in April with 6,086 volumes in Municipal
Building. Circulation for 1970-71 was 63,195 volumes.
Terrace View apartments, first large student complex, built
- 1971
- Town has new charter
Montgomery Regional Hospital built
- 1972
- Harding Avenue Elementary School
- 1973
- Blacksburg voters approve liquor by the drink by vote of 2,304 to 900
- 1974
- New Blacksburg High School on Patrick Henry Drive opens. The Main Street facilities were converted
to Blacksburg Middle School
University Mall shopping center opens
- 1975
- Jan Olinger is the first woman police officer
- 1976
- Deadwood Days summer festival begins (later renamed Steppin' Out)
- 1980
- Blacksburg Branch of the Montgomery-Floyd Regional Library moves into facility that used to house
Blacksburg Lumber Company on Draper Road
Warm Hearth Village retirement center built
- 1981
- Blacksburg Community Center built at cost of $1.2 million opens
Town opens first bikeway
- 1992
- Spring downpour floods Stroubles Creek through downtown and Donaldson Brown Center
- 1993
- Blacksburg Electronic Village begun
- 1994
- Severe ice storm knocks out electricity, drains town water supply
Kipps Elementary School opens
- 1996
- New Blacksburg branch library opens
First phase of the Huckleberry Trail opens
- 1997
- Ground broken for experimental "Smart Road"
- 1998
- Blacksburg's Bicentennial